PAD4 Antibody

• Background:

  PAD4 is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalyzation of the deimination of the arginine residues. PAD4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.

• NCBI Gene ID:

  23569

• Swiss Prot:

  Q9UM07

• Accession Number:

  Q9UM07

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 512-544 amino acids from the C-terminal region of human PAD4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  74 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PADI4

• NCBI Official Name:

  Protein-arginine deiminase type-4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nakayama-Hamada, M., et al., Biochem. Biophys. Res. Commun. 327 (1) :192-200 (2005) .

• Background Reference 02:

  Wang, Y., et al., Science 306 (5694) :279-283 (2004) .

• Background Reference 03:

  Arita, K., et al., Arthritis Rheum. 11 (8) :777-783 (2004) .

• Background Reference 04:

  Barton, A., et al., Arthritis Rheum. 50 (4) :1117-1121 (2004) .

• Other Product Names:

  Protein-arginine deiminase type-4, HL-60 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type IV, PADI4, PADI5, PDI5

• Tested Applications:

  WB

• Protein ID:

  296439260

• Physical Properties:

  Liquid