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PAD4 Antibody

CAT: 0223-61-423Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-423Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PAD4 is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalyzation of the deimination of the arginine residues. PAD4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.
NCBI Gene ID
23569
Swiss Prot
Q9UM07
Accession Number
Q9UM07
Host
Rabbit
Reactivity
Human
Immunogen
This PAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 512-544 amino acids from the C-terminal region of human PAD4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
74 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PADI4
NCBI Official Name
Protein-arginine deiminase type-4
NCBI Organism
Homo sapiens
Background Reference 01
Nakayama-Hamada, M., et al., Biochem. Biophys. Res. Commun. 327 (1) :192-200 (2005) .
Background Reference 02
Wang, Y., et al., Science 306 (5694) :279-283 (2004) .
Background Reference 03
Arita, K., et al., Arthritis Rheum. 11 (8) :777-783 (2004) .
Background Reference 04
Barton, A., et al., Arthritis Rheum. 50 (4) :1117-1121 (2004) .
Other Product Names
Protein-arginine deiminase type-4, HL-60 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type IV, PADI4, PADI5, PDI5
Tested Applications
WB
Protein ID
296439260
Physical Properties
Liquid

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