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WNK1 Antibody

CAT: 0223-61-362Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-61-362Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.
NCBI Gene ID
65125
Swiss Prot
Q9H4A3
Accession Number
Q9H4A3
Host
Rabbit
Reactivity
Human
Immunogen
This WNK1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1848-1882 amino acids from human WNK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
251 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
WNK1
NCBI Official Name
Serine/threonine-protein kinase WNK1
NCBI Organism
Homo sapiens
Background Reference 01
Verissimo F., et al.Oncogene 20:5562-5569 (2001) .
Background Reference 02
Vidal-Petiot E., et al.PLoS ONE 7:E37751-E37751 (2012) .
Background Reference 03
Scherer S.E., et al.Nature 440:346-351 (2006) .
Background Reference 04
Moore T.M., et al.J. Biol. Chem. 275:4311-4322 (2000) .
Other Product Names
Serine/threonine-protein kinase WNK1, 2.7.11.1, Erythrocyte 65 kDa protein, p65, Kinase deficient protein, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, hWNK1, WNK1, HSN2, KDP, KIAA0344, PRKWNK1
Tested Applications
WB
Protein ID
296453029
Physical Properties
Liquid

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