APIP Antibody

• Background:

  Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) . Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.

• NCBI Gene ID:

  51074

• Swiss Prot:

  Q96GX9

• Accession Number:

  Q96GX9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This APIP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 111-142 amino acids from the Central region of human APIP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  27 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  APIP

• NCBI Official Name:

  Methylthioribulose-1-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lai C.-H., et al.Genome Res. 10:703-713 (2000) .

• Background Reference 02:

  Ota T., et al.Nat. Genet. 36:40-45 (2004) .

• Background Reference 03:

  Taylor T.D., et al.Nature 440:497-500 (2006) .

• Background Reference 04:

  Cho D.-H., et al.J. Biol. Chem. 279:39942-39950 (2004) .

• Other Product Names:

  Methylthioribulose-1-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}, MTRu-1-P dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}, 4.2.1.109 {ECO:0000255|HAMAP-Rule:MF_03116}, APAF1-interacting protein {ECO:0000255|HAMAP-Rule:MF_03116}, hAPIP, APIP {ECO:0000255|HAMAP-Rule:MF_03116}

• Tested Applications:

  WB, IHC-P

• Protein ID:

  74731866

• Physical Properties:

  Liquid