API5 Antibody

• Background :

  Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

• NCBI Gene ID :

  8539

• Swiss Prot :

  Q9BZZ5

• Accession Number :

  Q9BZZ5

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This API5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-510 amino acids from the C-terminal region of human API5.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  59 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  API5

• NCBI Official Name :

  Apoptosis inhibitor 5

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Wang, Z., et al. Med. Sci. Monit. 16 (8), CR357-CR364 (2010) :

• Background Reference 02 :

  Ren, K., et al. Pathol. Oncol. Res. 16 (2) :229-237 (2010)

• Background Reference 03 :

  Need, A.C., et al. Hum. Mol. Genet. 18 (23) :4650-4661 (2009)

• Background Reference 04 :

  Rigou, P., et al. EMBO J. 28 (11) :1576-1588 (2009)

• Other Product Names :

  Apoptosis inhibitor 5, API-5, Antiapoptosis clone 11 protein, AAC-11, Cell migration-inducing gene 8 protein, Fibroblast growth factor 2-interacting factor, FIF, Protein XAGL, API5

• Tested Applications :

  WB

• Protein ID :

  353526346

• Physical Properties :

  Liquid