SH3PXD2B Antibody

• Background:

  Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity) .

• NCBI Gene ID:

  285590

• Swiss Prot:

  A1X283

• Accession Number:

  A1X283

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SH3PXD2B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 596-628 amino acids from human SH3PXD2B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  102 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SH3PXD2B

• NCBI Official Name:

  SH3 and PX domain-containing protein 2B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hishida T., et al.FEBS J. 275:5576-5588 (2008) .

• Background Reference 02:

  Lanyi A., et al.Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.

• Background Reference 03:

  Schmutz J., et al.Nature 431:268-274 (2004) .

• Background Reference 04:

  Nagase T., et al.DNA Res. 7:65-73 (2000) .

• Other Product Names:

  SH3 and PX domain-containing protein 2B, Adapter protein HOFI, Factor for adipocyte differentiation 49, Tyrosine kinase substrate with four SH3 domains, SH3PXD2B, FAD49, KIAA1295, TKS4

• Tested Applications:

  WB, Flow

• Physical Properties:

  Liquid