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SH3PXD2A Antibody

CAT: 0223-58-571Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-571Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SH3PXD2A is required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns (3) P) and phosphatidylinositol 3,4-biphosphate (PtdIns (3,4) P2) . In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
NCBI Gene ID
9644
Swiss Prot
Q5TCZ1
Accession Number
Q5TCZ1
Host
Rabbit
Reactivity
Human
Immunogen
This SH3PXD2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-250 amino acids from the N-terminal region of human SH3PXD2A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
125 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SH3PXD2A
NCBI Official Name
SH3 and PX domain-containing protein 2A
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Laumet, G., et al. Neurosci. Lett. 468 (1) :1-2 (2010)
Background Reference 03
Crimaldi, L., et al. Exp. Cell Res. 315 (15) :2581-2592 (2009)
Background Reference 04
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Other Product Names
SH3 and PX domain-containing protein 2A, Adapter protein TKS5, Five SH3 domain-containing protein, SH3 multiple domains protein 1, Tyrosine kinase substrate with five SH3 domains, SH3PXD2A, FISH, KIAA0418, SH3MD1, TKS5
Tested Applications
WB
Protein ID
74746151
Physical Properties
Liquid

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