LRPPRC Antibody

• Background :

  May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly (A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly (A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity) .

• NCBI Gene ID :

  10128

• Swiss Prot :

  P42704

• Accession Number :

  P42704

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This LRPPRC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1203-1236 amino acids from human LRPPRC.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  158 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:2000

• Symbol :

  LRPPRC

• NCBI Official Name :

  Leucine-rich PPR motif-containing protein, mitochondrial

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Xu F., et al.Biochem. J. 382:331-336 (2004) .

• Background Reference 02 :

  Ota T., et al.Nat. Genet. 36:40-45 (2004) .

• Background Reference 03 :

  Hillier L.W., et al.Nature 434:724-731 (2005) .

• Background Reference 04 :

  Hou J., et al.In Vitro Cell. Dev. Biol. Anim. 30A:111-114 (1994) .

• Other Product Names :

  Leucine-rich PPR motif-containing protein, mitochondrial, 130 kDa leucine-rich protein, LRP 130, GP130, LRPPRC, LRP130

• Tested Applications :

  WB

• Protein ID :

  156632706

• Physical Properties :

  Liquid