KRT86 Antibody

• Background:

  The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.

• NCBI Gene ID:

  3892

• Swiss Prot:

  O43790

• Accession Number:

  O43790

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This KRT86 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the Central region of human KRT86.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  54 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  KRT86

• NCBI Official Name:

  Keratin, type II cuticular Hb6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  ZHANG, S.D., et al. EurDermatol 19 (5) :508-509 (2009)

• Background Reference 02:

  Feng, A.P., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25 (2) :141-144 (2008)

• Background Reference 03:

  Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

• Background Reference 04:

  Schweizer, J., et al. J. Cell Biol. 174 (2) :169-174 (2006)

• Other Product Names:

  Keratin, type II cuticular Hb6, Hair keratin K211, Keratin-86, K86, Type II hair keratin Hb6, Type-II keratin Kb26, KRT86, KRTHB6

• Tested Applications:

  WB

• Physical Properties:

  Liquid