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KRT86 Antibody

CAT: 0223-60-876Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-876Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.
NCBI Gene ID
3892
Swiss Prot
O43790
Accession Number
O43790
Host
Rabbit
Reactivity
Human
Immunogen
This KRT86 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the Central region of human KRT86.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
KRT86
NCBI Official Name
Keratin, type II cuticular Hb6
NCBI Organism
Homo sapiens
Background Reference 01
ZHANG, S.D., et al. EurDermatol 19 (5) :508-509 (2009)
Background Reference 02
Feng, A.P., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25 (2) :141-144 (2008)
Background Reference 03
Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)
Background Reference 04
Schweizer, J., et al. J. Cell Biol. 174 (2) :169-174 (2006)
Other Product Names
Keratin, type II cuticular Hb6, Hair keratin K211, Keratin-86, K86, Type II hair keratin Hb6, Type-II keratin Kb26, KRT86, KRTHB6
Tested Applications
WB
Physical Properties
Liquid

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