KRT80 Antibody

• Background:

  Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.

• NCBI Gene ID:

  144501

• Swiss Prot:

  Q6KB66

• Accession Number:

  Q6KB66

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This KRT80 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-432 amino acids from the C-terminal region of human KRT80.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  51 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  KRT80

• NCBI Official Name:

  Keratin, type II cytoskeletal 80

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Langbein, L., et al. J. Biol. Chem. 285 (47) :36909-36921 (2010)

• Background Reference 02:

  Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

• Background Reference 03:

  Schweizer, J., et al. J. Cell Biol. 174 (2) :169-174 (2006)

• Background Reference 04:

  Rogers, M.A., et al. J. Invest. Dermatol. 124 (3) :536-544 (2005)

• Other Product Names:

  Keratin, type II cytoskeletal 80, Cytokeratin-80, CK-80, Keratin-80, K80, Type-II keratin Kb20, KRT80, KB20

• Tested Applications:

  WB

• Protein ID:

  166218808

• Physical Properties:

  Liquid