KRT8 Antibody [K8.8]

• Background:

  KRT8, also called Cytokeratin 8, is a low molecular weight keratin of approximately 50 kDa. It participates in cellular differentiation and signal transduction, protects against apoptosis, stress and injury, and helps maintain cellular structural integrity. KRT8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas.

• NCBI Gene ID:

  3856

• Swiss Prot:

  P05787

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Human carcinoma keratin was used as the immunogen for this KRT8 antibody.

• Clonality:

  Monoclonal

• Clone:

  K8.8

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1

• Specificity:

  Does not react with rat

• Applications Notes:

  1. FFPE staining requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes. 2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

• Symbol:

  KRT8

• NCBI Official Name:

  Keratin 8

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  KRT8, CARD2, CK8, CYK8, K2C8, K8, KO, CK-8

• Tested Applications:

  WB, Flow, IHC, IF

• Physical Properties:

  Liquid