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MMACHC Antibody

CAT: 0223-60-875Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-875Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC.
NCBI Gene ID
25974
Swiss Prot
Q9Y4U1
Accession Number
Q9Y4U1
Host
Rabbit
Reactivity
Human
Immunogen
This MMACHC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the C-terminal region of human MMACHC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
32 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MMACHC
NCBI Official Name
Methylmalonic aciduria and homocystinuria type C protein
NCBI Organism
Homo sapiens
Background Reference 01
Froese, D.S., et al. Mol. Genet. Metab. 100 (1) :29-36 (2010)
Background Reference 02
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 03
Profitlich, L.E., et al. Mol. Genet. Metab. 98 (4) :344-348 (2009)
Background Reference 04
Kim, J., et al. J. Biol. Chem. 284 (48) :33418-33424 (2009)
Other Product Names
Methylmalonic aciduria and homocystinuria type C protein, MMACHC
Tested Applications
WB
Protein ID
85681045
Physical Properties
Liquid

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