SGOL2 Antibody

CAT: 0223-60-874Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-874Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity) . Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
NCBI Gene ID
151246
Swiss Prot
Q562F6
Accession Number
Q562F6
Host
Rabbit
Reactivity
Human
Immunogen
This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
145 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SGOL2
NCBI Official Name
Shugoshin-like 2
NCBI Organism
Homo sapiens
Background Reference 01
Tanno, Y., et al. Genes Dev. 24 (19) :2169-2179 (2010)
Background Reference 02
Ross, C.J., et al. Nat. Genet. 41 (12) :1345-1349 (2009)
Background Reference 03
Lee, J., et al. Nat. Cell Biol. 10 (1) :42-52 (2008)
Background Reference 04
Huang, H., et al. J. Cell Biol. 177 (3) :413-424 (2007)
Other Product Names
Shugoshin-like 2, Shugoshin-2, Sgo2, Tripin, SGOL2
Tested Applications
WB
Protein ID
85542144
Physical Properties
Liquid

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