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SGOL1 Antibody

CAT: 0223-59-021Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-021Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SGOL1 plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.
NCBI Gene ID
151648
Swiss Prot
Q5FBB7
Accession Number
Q5FBB7
Host
Rabbit
Reactivity
Human
Immunogen
This SGOL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human SGOL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
64 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SGOL1
NCBI Official Name
Shugoshin-like 1
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Okamoto, N., et al. Genes Cells 15 (5) :471-484 (2010)
Background Reference 03
Xu, Z., et al. Mol. Cell 35 (4) :426-441 (2009)
Background Reference 04
Gambe, A.E., et al. FEBS Lett. 583 (12) :1951-1956 (2009)
Other Product Names
Shugoshin-like 1, hSgo1, Serologically defined breast cancer antigen NY-BR-85, SGOL1, SGO1
Tested Applications
WB
Protein ID
74741474
Physical Properties
Liquid

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