RRM1 Antibody

CAT: 0223-60-858Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-858Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.
NCBI Gene ID
6240
Swiss Prot
P23921
Accession Number
P23921
Host
Rabbit
Reactivity
Human
Immunogen
This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
90 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RRM1
NCBI Official Name
Ribonucleoside-diphosphate reductase large subunit
NCBI Organism
Homo sapiens
Background Reference 01
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16 (10) :770-777 (2010)
Background Reference 02
Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)
Background Reference 03
Vinolas, N., et al. Lung Cancer (2010) In press :
Background Reference 04
Niida, H., et al. Genes Dev. 24 (4) :333-338 (2010)
Other Product Names
Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1
Tested Applications
WB
Protein ID
132608
Physical Properties
Liquid

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