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MBNL1 Antibody

CAT: 0223-60-833Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-833Size:400 µL
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Background
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU (U/G) Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
NCBI Gene ID
4154
Swiss Prot
Q9NR56
Accession Number
Q9NR56
Host
Rabbit
Reactivity
Human
Immunogen
This MBNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-284 amino acids from the C-terminal region of human MBNL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MBNL1
NCBI Official Name
Muscleblind-like protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Sen, S., et al. J. Biol. Chem. 285 (33) :25426-25437 (2010)
Background Reference 02
Arambula, J.F., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (38) :16068-16073 (2009)
Background Reference 03
Cardani, R., et al. Neuromuscul. Disord. 19 (5) :335-343 (2009)
Background Reference 04
Holt, I., et al. Am. J. Pathol. 174 (1) :216-227 (2009)
Other Product Names
Muscleblind-like protein 1, Triplet-expansion RNA-binding protein, MBNL1, EXP, KIAA0428, MBNL
Tested Applications
WB
Protein ID
17369313
Physical Properties
Liquid

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