CLDN14 Antibody

CAT: 0223-60-829Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-829Size:400 µL
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Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
NCBI Gene ID
23562
Swiss Prot
O95500
Accession Number
O95500
Host
Rabbit
Reactivity
Human
Immunogen
This CLDN14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the C-terminal region of human CLDN14.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
26 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CLDN14
NCBI Official Name
Claudin-14
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Thorleifsson, G., et al. Nat. Genet. 41 (8) :926-930 (2009)
Background Reference 03
Belguith, H., et al. Biochem. Biophys. Res. Commun. 385 (1) :1-5 (2009)
Background Reference 04
Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009) :
Other Product Names
Claudin-14, CLDN14
Tested Applications
WB
Physical Properties
Liquid

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