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HAVCR2 Antibody

CAT: 0223-60-816Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-816Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD4 (MIM 186940) -positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
NCBI Gene ID
84868
Swiss Prot
Q8TDQ0
Accession Number
Q8TDQ0
Host
Rabbit
Reactivity
Human
Immunogen
This HAVCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-194 amino acids from the Central region of human HAVCR2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
33 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
HAVCR2
NCBI Official Name
Hepatitis A virus cellular receptor 2
NCBI Organism
Homo sapiens
Background Reference 01
Cao, B., et al. Cancer Immunol. Immunother. 59 (12) :1851-1857 (2010)
Background Reference 02
Dorfman, D.M., et al. Hum. Pathol. 41 (10) :1486-1494 (2010)
Background Reference 03
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 04
Dardalhon, V., et al. J. Immunol. 185 (3) :1383-1392 (2010)
Other Product Names
Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, HAVCR2, TIM3, TIMD3
Tested Applications
WB
Protein ID
311033536
Physical Properties
Liquid

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