KRT72 Antibody

• Background:

  Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type II keratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This gene encodes a type II keratin that is specifically expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  140807

• Swiss Prot:

  Q14CN4

• Accession Number:

  Q14CN4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This KRT72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-342 amino acids from the Central region of human KRT72.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  56 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  KRT72

• NCBI Official Name:

  Keratin, type II cytoskeletal 72

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bertheau, P., et al. PLoS Med. (3), E90 (2007) :

• Background Reference 02:

  Schweizer, J., et al. J. Cell Biol. 174 (2) :169-174 (2006)

• Background Reference 03:

  Langbein, L., et al. J. Invest. Dermatol. 120 (4) :512-522 (2003)

• Background Reference 04:

  Porter, R.M., et al. Br. J. Dermatol. 145 (4) :558-568 (2001)

• Other Product Names:

  Keratin, type II cytoskeletal 72, Cytokeratin-72, CK-72, Keratin-72, K72, Type II inner root sheath-specific keratin-K6irs2, Type-II keratin Kb35, KRT72, K6IRS2, KB35, KRT6, KRT6IRS2

• Tested Applications:

  WB

• Protein ID:

  166218813

• Physical Properties:

  Liquid