PSMB5 Antibody

• Background:

  The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit) . Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  5693

• Swiss Prot:

  P28074

• Accession Number:

  P28074

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PSMB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the C-terminal region of human PSMB5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  28 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PSMB5

• NCBI Official Name:

  Proteasome subunit beta type-5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ri, M., et al. Leukemia 24 (8) :1506-1512 (2010)

• Background Reference 02:

  Lu, S., et al. Exp. Hematol. 37 (7) :831-837 (2009)

• Background Reference 03:

  Lu, S., et al. Exp. Hematol. 36 (10) :1278-1284 (2008)

• Background Reference 04:

  Oerlemans, R., et al. Blood 112 (6) :2489-2499 (2008)

• Other Product Names:

  Proteasome subunit beta type-5, Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X, PSMB5, LMPX, MB1, X

• Tested Applications:

  WB, IHC-P

• Protein ID:

  187608890

• Physical Properties:

  Liquid