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EIF4E Antibody

CAT: 0223-60-600Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-600Size:400 µL
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Background
EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Nonphosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs. this gene also interacts mutually exclusive with EIF4A1 and EIF4A2.
NCBI Gene ID
1977
Swiss Prot
P06730
Accession Number
P06730
Host
Rabbit
Reactivity
Human
Immunogen
This EIF4E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human EIF4E.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Zebrafish, Bovine, Mouse, Rabbit, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
25 kDa
Fragment
Rabbit Ig
Symbol
EIF4E
NCBI Official Name
Eukaryotic translation initiation factor 4E
NCBI Organism
Homo sapiens
Background Reference 01
Rychlik, W., J. Biol. Chem. 262 (22), 10434-10437 (1987)
Background Reference 02
Dorfman, J., Genomics (4), 785-788 (1991)
Background Reference 03
Pelletier, J., Genomics 10 (4), 1079-1082 (1991)
Background Reference 04
Whalen, S.G., J. Biol. Chem. 271 (20), 11831-11837 (1996)
Other Product Names
Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, EIF4E, EIF4EL1, EIF4F
Tested Applications
WB, IHC-P
Protein ID
1352435
Physical Properties
Liquid

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