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FBXW5 Antibody

CAT: 0223-60-576Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-576Size:400 µL
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Background
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.
NCBI Gene ID
54461
Swiss Prot
Q969U6
Accession Number
Q969U6
Host
Rabbit
Reactivity
Human
Immunogen
This FBXW5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-350 amino acids from the Central region of human FBXW5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
64 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FBXW5
NCBI Official Name
F-box/WD repeat-containing protein 5
NCBI Organism
Homo sapiens
Background Reference 01
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 02
Minoda, Y., et al. Biochem. Biophys. Res. Commun. 381 (3) :412-417 (2009)
Background Reference 03
Hu, J., et al. Genes Dev. 22 (7) :866-871 (2008)
Background Reference 04
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101 (44) :15724-15729 (2004)
Other Product Names
F-box/WD repeat-containing protein 5, F-box and WD-40 domain-containing protein 5, FBXW5, FBW5
Tested Applications
WB
Protein ID
44887886
Physical Properties
Liquid

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