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FBXW4 Antibody

CAT: 0223-60-930Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-930Size:400 µL
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Background
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
NCBI Gene ID
6468
Swiss Prot
P57775
Accession Number
P57775
Host
Rabbit
Reactivity
Human
Immunogen
This FBXW4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human FBXW4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
46 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FBXW4
NCBI Official Name
F-box/WD repeat-containing protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Everman, D.B., et al. Am. J. Med. Genet.140 (13) :1375-1383 (2006)
Background Reference 02
Kano, H., et al. Hum. Genet. 118 (3-4), 477-483 (2005) :
Background Reference 03
Kang, Y.S., et al. Mol. Cells 17 (3) :397-403 (2004)
Background Reference 04
Deloukas, P., et al. Nature 429 (6990) :375-381 (2004)
Other Product Names
F-box/WD repeat-containing protein 4, Dactylin, F-box and WD-40 domain-containing protein 4, FBXW4, FBW4, SHFM3
Tested Applications
WB
Protein ID
13124191
Physical Properties
Liquid

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