GAR1 Antibody

• Background:

  This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.

• NCBI Gene ID:

  54433

• Swiss Prot:

  Q9NY12

• Accession Number:

  Q9NY12

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human GAR1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Zebrafish, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  22 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GAR1

• NCBI Official Name:

  H/ACA ribonucleoprotein complex subunit 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kalsi, G., et al. Hum. Mol. Genet. 19 (12) :2497-2506 (2010)

• Background Reference 02:

  Hamma, T., et al. J. Biol. Chem. 285 (2) :805-809 (2010)

• Background Reference 03:

  Pigullo, S., et al. Pediatr Blood Cancer 52 (3) :376-378 (2009)

• Background Reference 04:

  Vasan, R.S., et al. BMC Med. Genet.SUPPL 1, S2 (2007) :

• Other Product Names:

  H/ACA ribonucleoprotein complex subunit 1, Nucleolar protein family A member 1, snoRNP protein GAR1, GAR1, NOLA1

• Tested Applications:

  WB

• Protein ID:

  51828015

• Physical Properties:

  Liquid