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GAR1 Antibody

CAT: 0223-60-507Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-507Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.
NCBI Gene ID
54433
Swiss Prot
Q9NY12
Accession Number
Q9NY12
Host
Rabbit
Reactivity
Human
Immunogen
This GAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human GAR1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Zebrafish, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GAR1
NCBI Official Name
H/ACA ribonucleoprotein complex subunit 1
NCBI Organism
Homo sapiens
Background Reference 01
Kalsi, G., et al. Hum. Mol. Genet. 19 (12) :2497-2506 (2010)
Background Reference 02
Hamma, T., et al. J. Biol. Chem. 285 (2) :805-809 (2010)
Background Reference 03
Pigullo, S., et al. Pediatr Blood Cancer 52 (3) :376-378 (2009)
Background Reference 04
Vasan, R.S., et al. BMC Med. Genet.SUPPL 1, S2 (2007) :
Other Product Names
H/ACA ribonucleoprotein complex subunit 1, Nucleolar protein family A member 1, snoRNP protein GAR1, GAR1, NOLA1
Tested Applications
WB
Protein ID
51828015
Physical Properties
Liquid

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