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Mouse Maf Antibody

CAT: 0223-60-478Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-478Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Maf acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE) -mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity) . Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha-and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding.
NCBI Gene ID
17132
Swiss Prot
P54843
Accession Number
P54843
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Maf antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of mouse Maf.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Human, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
38 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Maf
NCBI Official Name
Transcription factor Maf
NCBI Organism
Mus musculus
Background Reference 01
Nishikawa, K., et al. J. Clin. Invest. 120 (10) :3455-3465 (2010)
Background Reference 02
Apetoh, L., et al. Nat. Immunol. 11 (9) :854-861 (2010)
Background Reference 03
Wang, W.L., et al. Mol. Biol. Cell 21 (14) :2453-2468 (2010)
Background Reference 04
Honma, Y., et al. Development 137 (14) :2319-2328 (2010)
Other Product Names
Transcription factor Maf, Proto-oncogene c-Maf, V-maf musculoaponeurotic fibrosarcoma oncogene homolog, Maf, Maf2
Tested Applications
WB
Physical Properties
Liquid

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