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MAFF Antibody

CAT: 0223-28-990Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-28-990Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAFF is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. MAFF can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. MAFF may also be involved in the cellular stress response.The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Two transcript variants encoding the same protein have been found for this gene.
NCBI Gene ID
23764
Swiss Prot
Q9ULX9
Accession Number
NP_690617
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Zebrafish, Drosophila
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MAFF.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MAFF antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
18 kDa, 18 kDa, 18 kDa, 18 kDa, 18 kDa
Applications Notes
MAFF antibody can be used for detection of MAFF by ELISA at 1:62500. MAFF antibody can be used for detection of MAFF by western blot at 5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
MAFF
NCBI Official Name
V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NCBI Organism
Homo sapiens
Background Reference 01
Marini, M.G., (2002) Blood Cells Mol. Dis. 29 (2), 145-158.
Other Product Names
MAFF, U-MAF, hMafF
Tested Applications
ELISA, WB
Protein ID
23111003
Physical Properties
Liquid

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