MAFA Antibody

• Background:

  MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]) .

• NCBI Gene ID:

  389692

• Swiss Prot:

  Q8NHW3

• Accession Number:

  Q8NHW3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the C-terminal region of human MAFA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MAFA

• NCBI Official Name:

  Transcription factor MafA

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lecoin, L., et al. Dev Neurobiol 70 (7) :485-497 (2010)

• Background Reference 02:

  Guo, S., et al. J. Biol. Chem. 285 (17) :12655-12661 (2010)

• Background Reference 03:

  Kondo, T., et al. Mol. Endocrinol. 23 (8) :1281-1290 (2009)

• Background Reference 04:

  Kaneto, H., et al. Adv. Drug Deliv. Rev. 61 (7-8), 489-496 (2009) :

• Other Product Names:

  Transcription factor MafA, Pancreatic beta-cell-specific transcriptional activator, Transcription factor RIPE3b1, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A, MAFA

• Tested Applications:

  WB

• Protein ID:

  296435511

• Physical Properties:

  Liquid