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Mouse Xaf1 Antibody

CAT: 0223-60-474Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-474Size:400 µL
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Background
Xaf1 seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity) .
NCBI Gene ID
327959
Swiss Prot
Q5NBU8
Accession Number
Q5NBU8
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Xaf1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the Central region of mouse Xaf1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
31 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Xaf1
NCBI Official Name
XIAP-associated factor 1
NCBI Organism
Mus musculus
Background Reference 01
Bai, Y., et al. J. Biol. Chem. 283 (11) :6832-6842 (2008)
Background Reference 02
Qiao, L., et al. Tumour Biol. 29 (2) :122-129 (2008)
Background Reference 03
Wang, X., et al. Neurobiol. Dis. 16 (1) :179-189 (2004)
Background Reference 04
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100 (24) :14109-14114 (2003)
Other Product Names
XIAP-associated factor 1, BIRC4-binding protein, Xaf1, Birc4bp, Xiapaf1
Tested Applications
WB
Physical Properties
Liquid

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