NR2C2 Antibody

• Background:

  Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes (Yoshikawa et al., 1996 [PubMed 8661150]) .

• NCBI Gene ID:

  7182

• Swiss Prot:

  P49116

• Accession Number:

  P49116

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NR2C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-466 amino acids from the C-terminal region of human NR2C2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  65 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NR2C2

• NCBI Official Name:

  Nuclear receptor subfamily 2 group C member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Srivastava, R., et al. J. Biol. Chem. 285 (15) :11100-11105 (2010)

• Background Reference 03:

  Ear, T., et al. J. Immunol. 184 (7) :3897-3906 (2010)

• Background Reference 04:

  Suzuki, S., et al. J. Biol. Chem. 285 (7) :4441-4446 (2010)

• Other Product Names:

  Nuclear receptor subfamily 2 group C member 2, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, Testicular receptor 4, NR2C2, TAK1, TR4

• Tested Applications:

  WB, IF

• Protein ID:

  1351190

• Physical Properties:

  Liquid