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SIRPB1 Antibody

CAT: 0223-60-449Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-449Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
10326
Swiss Prot
O00241
Accession Number
O00241
Host
Rabbit
Reactivity
Human
Immunogen
This SIRPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-134 amino acids from the Central region of human SIRPB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SIRPB1
NCBI Official Name
Signal-regulatory protein beta-1
NCBI Organism
Homo sapiens
Background Reference 01
Gaikwad, S., et al. Am. J. Pathol. 175 (6) :2528-2539 (2009)
Background Reference 02
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259 (3) :151-163 (2009)
Background Reference 03
Martins-de-Souza, D., et al.Neural Transm 116 (3) :275-289 (2009)
Background Reference 04
Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)
Other Product Names
Signal-regulatory protein beta-1, SIRP-beta-1, CD172 antigen-like family member B, CD172b, SIRPB1
Tested Applications
WB
Physical Properties
Liquid

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