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IsocitRe dehydrogenase Antibody

CAT: 0223-60-430Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-430Size:400 µL
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Background
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD (+) -dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein described here is the alpha subunit of one isozyme of NAD (+) -dependent isocitrate dehydrogenase.
NCBI Gene ID
3419
Swiss Prot
P50213
Accession Number
P50213
Host
Rabbit
Reactivity
Human
Immunogen
This Isocitrate dehydrogenase (IDH3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids from the C-terminal region of human Isocitrate dehydrogenase (IDH3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
40 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
IDH3A
NCBI Official Name
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Soundar, S., et al., J. Biol. Chem. 278 (52) :52146-52153 (2003) .
Background Reference 02
Weiss, C., et al., Biochemistry 39 (7) :1807-1816 (2000) .
Background Reference 03
Kim, Y.O., et al., J. Biol. Chem. 274 (52) :36866-36875 (1999) .
Background Reference 04
Huh, T.L., et al., Genomics 32 (2) :295-296 (1996) .
Other Product Names
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitric dehydrogenase subunit alpha, NAD (+) -specific ICDH subunit alpha, IDH3A
Tested Applications
WB
Protein ID
1708399
Physical Properties
Liquid

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