Isocitrate Dehydrogenase Recombinant Protein

• Background:

  Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1) belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 exists as a homodimer, binding one magnesium or manganese ion per subunit. Mutations of IDH1 have been shown to cause metaphyseal chondromatosis with aciduria and are involved in the development of glioma IDH plays a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid.

• NCBI Gene ID:

  3417

• Swiss Prot:

  O75874

• Accession Number:

  O75874

• Tag:

  C-8 His tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Homeostasis, Signal Transduction, Other

• Buffer:

  Supplied as a 0.2 um filtered solution of 50mM Tris, 200mM NaCl, 10% glycerol, pH8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  48.1 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Isocitrate dehydrogenase 1 (NADP+)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Isocitrate Dehydrogenase [NADP] Cytoplasmic, IDH, Cytosolic NADP-Isocitrate Dehydrogenase, IDP, NADP (+) -Specific ICDH, Oxalosuccinate Decarboxylase, IDH1, PICD

• Species:

  Human

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3