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Mouse Shb Antibody

CAT: 0223-60-411Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-411Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells (By similarity) .
NCBI Gene ID
230126
Swiss Prot
Q6PD21
Accession Number
Q6PD21
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Shb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-95 amino acids from the C-terminal region of mouse Shb.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Human
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
55 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Shb
NCBI Official Name
SH2 domain-containing adapter protein B
NCBI Organism
Mus musculus
Background Reference 01
Calounova, G., et al. PLoS ONE (6), E11155 (2010) :
Background Reference 02
Akerblom, B., et al. J. Endocrinol. 203 (2) :271-279 (2009)
Background Reference 03
Mokhtari, D., et al. Biochem. Biophys. Res. Commun. 387 (3) :553-557 (2009)
Background Reference 04
Funa, N.S., et al. Cancer Res. 69 (5) :2141-2148 (2009)
Other Product Names
SH2 domain-containing adapter protein B, Shb
Tested Applications
WB
Physical Properties
Liquid

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