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Elongin A Antibody

CAT: 0223-60-375Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-375Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
NCBI Gene ID
6924
Swiss Prot
Q14241
Accession Number
Q14241
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This Elongin A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-127 amino acids from the N-terminal region of human Elongin A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
90 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TCEB3
NCBI Official Name
Transcription elongation factor B polypeptide 3
NCBI Organism
Homo sapiens
Background Reference 01
Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101 (33) :12130-12135 (2004) .
Background Reference 02
Tamura, K., et al., Biochem. Biophys. Res. Commun. 309 (1) :189-195 (2003) .
Background Reference 03
Kile, B.T., et al., Trends Biochem. Sci. 27 (5) :235-241 (2002) .
Background Reference 04
Yamazaki, K., et al., J. Biol. Chem. 277 (29) :26444-26451 (2002) .
Other Product Names
Transcription elongation factor B polypeptide 3, Elongin 110 kDa subunit, Elongin-A, EloA, RNA polymerase II transcription factor SIII subunit A1, SIII p110, TCEB3
Tested Applications
WB
Protein ID
294862430
Physical Properties
Liquid

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