RNF6 Antibody

• Background:

  The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.

• NCBI Gene ID:

  6049

• Swiss Prot:

  Q9Y252

• Accession Number:

  Q9Y252

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RNF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529-558 amino acids from the C-terminal region of human RNF6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  78 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  RNF6

• NCBI Official Name:

  E3 ubiquitin-protein ligase RNF6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Xu, K., et al. Cancer Cell 15 (4) :270-282 (2009)

• Background Reference 02:

  Zhu, L., et al. Sci. China, C, Life Sci. 51 (4) :302-307 (2008)

• Background Reference 03:

  Tursun, B., et al. Genes Dev. 19 (19) :2307-2319 (2005)

• Background Reference 04:

  Lo, H.S., et al. Cancer Res. 62 (15) :4191-4193 (2002)

• Other Product Names:

  E3 ubiquitin-protein ligase RNF6, 632-, RNF6, SPG2

• Tested Applications:

  WB

• Protein ID:

  13124536

• Physical Properties:

  Liquid