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KDELR1 Antibody

CAT: 0223-60-332Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-332Size:400 µL
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Background
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.
NCBI Gene ID
10945
Swiss Prot
P24390
Accession Number
P24390
Host
Rabbit
Reactivity
Human
Immunogen
This KDELR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the C-terminal region of human KDELR1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat, Zebrafish, Chicken, Xenopus, B
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
25 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
KDELR1
NCBI Official Name
ER lumen protein-retaining receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Background Reference 02
Breuza, L., et al. J. Biol. Chem. 279 (45) :47242-47253 (2004)
Background Reference 03
Bard, F., et al. J. Biol. Chem. 278 (47) :46601-46606 (2003)
Background Reference 04
Yamamoto, K., et al. J. Biol. Chem. 278 (36) :34525-34532 (2003)
Other Product Names
ER lumen protein-retaining receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, KDEL receptor 1, Putative MAPK-activating protein PM23, KDELR1, ERD21
Tested Applications
WB
Protein ID
119543
Physical Properties
Liquid

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