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KDELR2 Antibody

CAT: 0223-57-940Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-940Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
NCBI Gene ID
11014
Swiss Prot
P33947
Accession Number
P33947
Host
Rabbit
Reactivity
Human
Immunogen
This KDELR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human KDELR2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Xenopus, Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
24 kDa
Fragment
Rabbit Ig
Symbol
KDELR2
NCBI Official Name
ER lumen protein-retaining receptor 2
NCBI Organism
Homo sapiens
Background Reference 01
Van der Vlies, D., et al. Biochem. J. 366 (PT 3), 825-830 (2002) :
Background Reference 02
Pelham, H.R. Cell Struct. Funct. 21 (5) :413-419 (1996)
Background Reference 03
Lewis, M.J., et al. J. Mol. Biol. 226 (4) :913-916 (1992)
Background Reference 04
Hsu, V.W., et al. Cell 69 (4) :625-635 (1992)
Other Product Names
ER lumen protein-retaining receptor 2, ERD2-like protein 1, ELP-1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2, KDELR2, ERD22
Tested Applications
WB, IHC-P
Protein ID
462018
Physical Properties
Liquid

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