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SUV39H2 Antibody

CAT: 0223-60-326Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-326Size:400 µL
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Background
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
NCBI Gene ID
79723
Swiss Prot
Q9H5I1
Accession Number
Q9H5I1
Host
Rabbit
Reactivity
Human
Immunogen
This SUV39H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-395 amino acids from the C-terminal region of human SUV39H2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SUV39H2
NCBI Official Name
Histone-lysine N-methyltransferase SUV39H2
NCBI Organism
Homo sapiens
Background Reference 01
Sun, X.J., et al. PLoS ONE (1), E1499 (2008) :
Background Reference 02
Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)
Background Reference 03
Yoon, K.A., et al. Carcinogenesis 27 (11) :2217-2222 (2006)
Background Reference 04
Frontelo, P., et al. Oncogene 23 (30) :5242-5251 (2004)
Other Product Names
Histone-lysine N-methyltransferase SUV39H2, Histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, Lysine N-methyltransferase 1B, Suppressor of variegation 3-9 homolog 2, Su (var) 3-9 homolog 2, SUV39H2, KMT1B
Tested Applications
WB
Protein ID
25091325
Physical Properties
Liquid

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