RFC1 Antibody

• Background:

  The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability. [provided by RefSeq].

• NCBI Gene ID:

  5981

• Swiss Prot:

  P35251

• Accession Number:

  P35251

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RFC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human RFC1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  128 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  RFC1

• NCBI Official Name:

  Replication factor C subunit 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Overmeer, R.M., et al. Mol. Cell. Biol. 30 (20) :4828-4839 (2010) Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010) Arora, M., et al. Leukemia 24 (8) :1470-1475 (2010) Galbiatti, A.L., et al. Mol. Biol. Rep. (2010) In pressJugessur, A., et al. PLoS ONE (7), E11493 (2010) :

• Other Product Names:

  Replication factor C subunit 1, Activator 1 140 kDa subunit, A1 140 kDa subunit, Activator 1 large subunit, Activator 1 subunit 1, DNA-binding protein PO-GA, Replication factor C 140 kDa subunit, RF-C 140 kDa subunit, RFC140, Replication factor C large subunit, RFC1, RFC140

• Tested Applications:

  WB

• Protein ID:

  56757608

• Physical Properties:

  Liquid