RASA3 Antibody

• Background:

  The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.

• NCBI Gene ID:

  22821

• Swiss Prot:

  Q14644

• Accession Number:

  Q14644

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This RASA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 594-623 amino acids from the C-terminal region of human RASA3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  96 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  RASA3

• NCBI Official Name:

  Ras GTPase-activating protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kupzig, S., et al. Mol. Cell. Biol. 29 (14) :3929-3940 (2009)

• Background Reference 02:

  Rush, J., et al. Nat. Biotechnol. 23 (1) :94-101 (2005)

• Background Reference 03:

  Walker, S.A., et al. J. Biol. Chem. 277 (50) :48779-48785 (2002)

• Background Reference 04:

  Koehler, J.A., et al. Biochem. Biophys. Res. Commun. 283 (4) :888-895 (2001)

• Other Product Names:

  Ras GTPase-activating protein 3, GAP1 (IP4BP), Ins P4-binding protein, RASA3

• Tested Applications:

  WB

• Protein ID:

  206729910

• Physical Properties:

  Liquid