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RASA3 Antibody

CAT: 0223-60-278Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-278Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
NCBI Gene ID
22821
Swiss Prot
Q14644
Accession Number
Q14644
Host
Rabbit
Reactivity
Human
Immunogen
This RASA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 594-623 amino acids from the C-terminal region of human RASA3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
96 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RASA3
NCBI Official Name
Ras GTPase-activating protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Kupzig, S., et al. Mol. Cell. Biol. 29 (14) :3929-3940 (2009)
Background Reference 02
Rush, J., et al. Nat. Biotechnol. 23 (1) :94-101 (2005)
Background Reference 03
Walker, S.A., et al. J. Biol. Chem. 277 (50) :48779-48785 (2002)
Background Reference 04
Koehler, J.A., et al. Biochem. Biophys. Res. Commun. 283 (4) :888-895 (2001)
Other Product Names
Ras GTPase-activating protein 3, GAP1 (IP4BP), Ins P4-binding protein, RASA3
Tested Applications
WB
Protein ID
206729910
Physical Properties
Liquid

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