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RASA1 Antibody

CAT: 0223-56-754Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-754Size:400 µL
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Background
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
NCBI Gene ID
5921
Swiss Prot
P20936
Accession Number
P20936
Host
Rabbit
Reactivity
Human
Immunogen
This RASA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 966-993 amino acids from the C-terminal region of human RASA1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
116 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RASA1
NCBI Official Name
Ras GTPase-activating protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Hemerly, J.P., et al. Eur. J. Endocrinol. 163 (5) :747-755 (2010)
Background Reference 02
Wiemels, J.L., et al. Blood Cells Mol. Dis. 45 (3) :186-191 (2010)
Background Reference 03
Bachas, C., et al. Blood 116 (15) :2752-2758 (2010)
Background Reference 04
Oinuma, I., et al. J. Biol. Chem. 285 (36) :28200-28209 (2010)
Other Product Names
Ras GTPase-activating protein 1, GAP, GTPase-activating protein, RasGAP, Ras p21 protein activator, p120GAP, RASA1, GAP, RASA
Tested Applications
WB
Protein ID
121743
Physical Properties
Liquid

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