MCCC2 Antibody

• Background:

  This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism.

• NCBI Gene ID:

  64087

• Swiss Prot:

  Q9HCC0

• Accession Number:

  Q9HCC0

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MCCC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 468-496 amino acids from the C-terminal region of human MCCC2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  61 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MCCC2

• NCBI Official Name:

  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010) Oguri, M., et al. Am. J. Hypertens. 23 (1) :70-77 (2010) Cho, Y.S., et al. Proteins 70 (1) :268-272 (2008) Uematsu, M., et al. J. Hum. Genet. 52 (12) :1040-1043 (2007) Stadler, S.C., et al. Biochem. Biophys. Res. Commun. 334 (3) :939-946 (2005)

• Other Product Names:

  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, MCCase subunit beta, 3-methylcrotonyl-CoA carboxylase 2, 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit, 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta, MCCC2, MCCB

• Tested Applications:

  WB

• Protein ID:

  20138731

• Physical Properties:

  Liquid