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SCN5A Antibody

CAT: 0223-60-210Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-210Size:400 µL
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Background
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.
NCBI Gene ID
6331
Swiss Prot
Q14524
Accession Number
Q14524
Host
Rabbit
Reactivity
Human
Immunogen
This SCN5A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human SCN5A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
227 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SCN5A
NCBI Official Name
Sodium channel protein type 5 subunit alpha
NCBI Organism
Homo sapiens
Background Reference 01
Liu, M., et al. Circ. Res. 107 (8) :967-974 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Van Stuijvenberg, L., et al. DNA Cell Biol. 29 (10) :577-587 (2010)
Background Reference 04
House, C.D., et al. Cancer Res. 70 (17) :6957-6967 (2010)
Other Product Names
Sodium channel protein type 5 subunit alpha, HH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav15, SCN5A
Tested Applications
WB
Protein ID
215273881
Physical Properties
Liquid

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