PCGF6 Antibody

• Background:

  The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.

• NCBI Gene ID:

  84108

• Swiss Prot:

  Q9BYE7

• Accession Number:

  Q9BYE7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PCGF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-217 amino acids from the Central region of human PCGF6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PCGF6

• NCBI Official Name:

  Polycomb group RING finger protein 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lee, J.Y., et al. Cancer Res. 68 (11) :4201-4209 (2008)

• Background Reference 02:

  Zhang, J., et al. J. Biol. Chem. 283 (12) :7464-7469 (2008)

• Background Reference 03:

  Lee, M.G., et al. Cell 128 (5) :877-887 (2007)

• Background Reference 04:

  Zhong, N., et al. Biochem. Biophys. Res. Commun. 338 (2) :855-861 (2005)

• Other Product Names:

  Polycomb group RING finger protein 6, Mel18 and Bmi1-like RING finger, RING finger protein 134, PCGF6, MBLR, RNF134

• Tested Applications:

  WB

• Protein ID:

  116242703

• Physical Properties:

  Liquid