PCGF2 Antibody

• Background:

  The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

• NCBI Gene ID:

  7703

• Swiss Prot:

  P35227

• Accession Number:

  P35227

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PCGF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-150 amino acids from the Central region of human PCGF2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  38 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PCGF2

• NCBI Official Name:

  Polycomb group RING finger protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jung, J.H., et al. Biochem. Biophys. Res. Commun. 400 (4) :523-530 (2010)

• Background Reference 02:

  Zhang, X.W., et al. Mol. Cancer 9, 40 (2010) :

• Background Reference 03:

  Wang, W., et al. Int. J. Cancer 125 (12) :2836-2843 (2009)

• Background Reference 04:

  Zhang, J., et al. Biochem. Biophys. Res. Commun. 375 (2) :252-255 (2008)

• Other Product Names:

  Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, PCGF2, MEL18, RNF110, ZNF144

• Tested Applications:

  WB

• Protein ID:

  462585

• Physical Properties:

  Liquid