ITGA7 Antibody

• Background:

  The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

• NCBI Gene ID:

  3679

• Swiss Prot:

  Q13683

• Accession Number:

  Q13683

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ITGA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-257 amino acids from the N-terminal region of human ITGA7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  129 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ITGA7

• NCBI Official Name:

  Integrin alpha-7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)

• Background Reference 02:

  Han, Y.C., et al. Cancer Res. 70 (11) :4375-4384 (2010)

• Background Reference 03:

  Rooney, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (19) :7991-7996 (2009)

• Background Reference 04:

  Liu, J., et al. J. Biol. Chem. 283 (51) :35668-35678 (2008)

• Other Product Names:

  Integrin alpha-7, Integrin alpha-7 heavy chain, Integrin alpha-7 light chain, Integrin alpha-7 70 kDa form, ITGA7

• Tested Applications:

  WB

• Protein ID:

  308153592

• Physical Properties:

  Liquid