ITGA5 Antibody

• Background :

  The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].

• NCBI Gene ID :

  3678

• Swiss Prot :

  P08648

• Accession Number :

  P08648

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This ITGA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 796-822 amino acids from the C-terminal region of human ITGA5.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  115 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  ITGA5

• NCBI Official Name :

  Integrin alpha-5

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Kim, S., et al. Carcinogenesis 31 (4) :597-606 (2010)

• Background Reference 02 :

  Ryu, M.H., et al. Biochem. Biophys. Res. Commun. 393 (1) :11-15 (2010)

• Background Reference 03 :

  Yang, Y., et al. J. Biol. Chem. 285 (1) :131-141 (2010)

• Background Reference 04 :

  Lowin, T., et al. Arthritis Rheum. 60 (12) :3623-3632 (2009)

• Other Product Names :

  Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA

• Tested Applications :

  WB, Flow

• Protein ID :

  23831237

• Physical Properties :

  Liquid