MMS19 Antibody

• Background :

  MMS19 may play a role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription by interacting with ERCC2/XPD and ERCC3/XPB helicases, both subunits of NER-transcription factor TFIIH. May also function as a transcriptional coactivator of estrogen receptor (ER) . May be involved in regulation of ER activity by bridging TFIIH with ER or may facilitate TFIIH-mediated phosphorylation of ER in specific promoters and cell types.

• NCBI Gene ID :

  64210

• Swiss Prot :

  Q96T76

• Accession Number :

  Q96T76

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This MMS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 411-437 amino acids from the Central region of human MMS19.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  113 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  MMS19

• NCBI Official Name :

  MMS19 nucleotide excision repair protein homolog

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Ito, S., et al. Mol. Cell 39 (4) :632-640 (2010)

• Background Reference 02 :

  Briggs, F.B., et al. Am. J. Epidemiol. 172 (2) :217-224 (2010)

• Background Reference 03 :

  McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18 (4) :1295-1302 (2009)

• Background Reference 04 :

  Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

• Other Product Names :

  MMS19 nucleotide excision repair protein homolog, hMMS19, MET18 homolog, MMS19-like protein, MMS19, MMS19L

• Tested Applications :

  WB

• Protein ID :

  150421597

• Physical Properties :

  Liquid