CLCF1 Antibody

CAT: 0223-60-119Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-119Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the glycoprotein (gp) 130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1) . CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1) . This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2) . This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
NCBI Gene ID
23529
Swiss Prot
Q9UBD9
Accession Number
Q9UBD9
Host
Rabbit
Reactivity
Human
Immunogen
This CLCF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human CLCF1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
25 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CLCF1
NCBI Official Name
Cardiotrophin-like cytokine factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Rousseau, F., et al. J. Biol. Chem. 283 (44) :30341-30350 (2008)
Background Reference 02
Dagoneau, N., et al. Am. J. Hum. Genet. 80 (5) :966-970 (2007)
Background Reference 03
Rousseau, F., et al. Proc. Natl. Acad. Sci. U.S.A. 103 (26) :10068-10073 (2006)
Background Reference 04
Perret, D., et al. J. Biol. Chem. 279 (42) :43961-43970 (2004)
Other Product Names
Cardiotrophin-like cytokine factor 1, B-cell-stimulating factor 3, BSF-3, Novel neurotrophin-1, NNT-1, CLCF1, BSF3, CLC, NNT1
Tested Applications
WB
Protein ID
56404673
Physical Properties
Liquid

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