TRPC4AP Antibody

• Background:

  Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX (TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca (2+) storage reduction in response to CHRM1.

• NCBI Gene ID:

  26133

• Swiss Prot:

  Q8TEL6

• Accession Number:

  Q8TEL6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TRPC4AP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-75 amino acids from the N-terminal region of human TRPC4AP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  91 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TRPC4AP

• NCBI Official Name:

  Short transient receptor potential channel 4-associated protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mace, K.E., et al. J. Cell. Physiol. 225 (2) :444-453 (2010)

• Background Reference 02:

  Choi, S.H., et al. Genes Dev. 24 (12) :1236-1241 (2010)

• Background Reference 03:

  Poduslo, S.E., et al. Neurosci. Lett. 450 (3) :344-346 (2009)

• Background Reference 04:

  Poduslo, S.E., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (1), 50-55 (2009) :

• Other Product Names:

  Short transient receptor potential channel 4-associated protein, Trp4-associated protein, Trpc4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein, Protein TRUSS, TRPC4AP, C20orf188, TRRP4AP

• Tested Applications:

  WB

• Protein ID:

  25091357

• Physical Properties:

  Liquid