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TRPC4AP Antibody

CAT: 0223-60-059Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-059Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX (TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca (2+) storage reduction in response to CHRM1.
NCBI Gene ID
26133
Swiss Prot
Q8TEL6
Accession Number
Q8TEL6
Host
Rabbit
Reactivity
Human
Immunogen
This TRPC4AP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-75 amino acids from the N-terminal region of human TRPC4AP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
91 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TRPC4AP
NCBI Official Name
Short transient receptor potential channel 4-associated protein
NCBI Organism
Homo sapiens
Background Reference 01
Mace, K.E., et al. J. Cell. Physiol. 225 (2) :444-453 (2010)
Background Reference 02
Choi, S.H., et al. Genes Dev. 24 (12) :1236-1241 (2010)
Background Reference 03
Poduslo, S.E., et al. Neurosci. Lett. 450 (3) :344-346 (2009)
Background Reference 04
Poduslo, S.E., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (1), 50-55 (2009) :
Other Product Names
Short transient receptor potential channel 4-associated protein, Trp4-associated protein, Trpc4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein, Protein TRUSS, TRPC4AP, C20orf188, TRRP4AP
Tested Applications
WB
Protein ID
25091357
Physical Properties
Liquid

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