ECH1 Antibody

CAT: 0223-59-987Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-59-987Size:400 µL
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Background
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.
NCBI Gene ID
1891
Swiss Prot
Q13011
Accession Number
Q13011
Host
Rabbit
Reactivity
Human
Immunogen
This ECH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-250 amino acids from the C-terminal region of human ECH1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
36 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ECH1
NCBI Official Name
Delta (3,5) -Delta (2,4) -dienoyl-CoA isomerase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Background Reference 02
Olsen, J.V., et al. Cell 127 (3) :635-648 (2006)
Background Reference 03
Kovalyov, L.I., et al. Biochemistry Mosc. 71 (4) :448-453 (2006)
Background Reference 04
Goehler, H., et al. Mol. Cell 15 (6) :853-865 (2004)
Other Product Names
Delta (3,5) -Delta (2,4) -dienoyl-CoA isomerase, mitochondrial, 533-, ECH1
Tested Applications
WB
Protein ID
82654933
Physical Properties
Liquid

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